Antibodies binding to VISTA at acidic pH

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United States of America

PATENT NO 12195535
APP PUB NO 20240092907A1
SERIAL NO

18162991

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Abstract

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The present application relates to antibodies specifically binding to the V-domain immunoglobulin-containing suppressor of T-cell activation (VISTA) at acidic pH and their use in cancer treatment. In some embodiments, the antibodies bind specifically to human VISTA at acidic pH, but do not significantly bind to human VISTA at neutral or physiological pH.

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Patent Owner(s)

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BRISTOL-MYERS SQUIBB COMPANYROUTE 206 & PROVINCE LINE ROAD PRINCETON NJ 08543

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bahjat, Keith Sadoon Woodside, US 5 8
Borges, Luis Houston, US 26 53
Deng, Andy X Princeton, US 12 18
Johnston, Robert J San Mateo, US 59 515
Korman, Alan J Piedmont, US 132 5349
Rajpal, Arvind San Francisco, US 78 1224
Rakestraw, Ginger Somerville, US 13 20
Rankin, Andrew Redwood City, US 15 21
Sheppard, Paul O Granite Falls, US 305 2907
Su, Lin Hui Somerville, US 9 9

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