Therapeutic variant alpha-2-macroglobulin compositions

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United States of America

PATENT NO 12195521
APP PUB NO 20230250154A1
SERIAL NO

18178917

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Abstract

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A2M polypeptide compositions containing a non-natural bait region are disclosed. Methods of producing wild-type and variant A2M polypeptides and polynucleotides containing a non-natural bait region are also disclosed. The bait regions of the variant A2M polypeptides demonstrate enhanced protease inhibitory characteristics compared to wild-type A2M. Variant A2M polypeptides that demonstrate longer half-lives upon administration to an organism compared to wild-type A2M are disclosed. The A2M compositions are useful in treating a number of diseases and conditions including inflammation, chronic wounds, and diseases with a pathology associated with proteases.

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Patent Owner(s)

Patent OwnerAddress
CYTONICS CORPORATION658 WEST INDIANTOWN ROAD JUPITER FL 33458

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Browning, Shawn Robert Jupiter, US 10 38
Hanna, Lewis Naples, US 10 38
Laughlin, John David Jupiter, US 13 123

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