Small molecule neutral sphingomyelinase 2 (nSMase2) inhibitors

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United States of America

PATENT NO 12195450
APP PUB NO 20220119374A1
SERIAL NO

17422670

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Abstract

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Small molecule inhibitors of neutral sphingomyelinase 2 (nSMase2) and their use for treating neurodegenerative diseases, such as, neurodegenerative diseases associated with high levels of ceramide, including, but not limited to Alzheimer's disease (AD), HIV-associated neurocognitive disorder (HAND), multiple sclerosis (MS), and amyotrophic lateral sclerosis (ALS), and, in other aspects, for treating cancer or HIV-1, are provided.

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Patent Owner(s)

Patent OwnerAddress
THE JOHNS HOPKINS UNIVERSITY34TH AND CHARLES STREET BALTIMORE MD 21218

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hin, Niyada Laurel, US 2 0
Rojas, Camilo Baltimore, US 10 1
Slusher, Barbara Kingsville, US 45 104
Stepanek, Ondrej Baltimore, US 2 0
Thomas, Ajit G Baltimore, US 3 1
Tsukamoto, Takashi Ellicott City, US 127 1564

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