Dosing parameters for CD47 targeting therapies to hematologic malignancies

Number of patents in Portfolio can not be more than 2000

United States of America

PATENT NO 12194093
APP PUB NO 20230270852A1
SERIAL NO

18143978

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Methods are provided herein for determining and administering optimized dosing of therapeutic anti-CD47 agents, in a schedule that provides safe escalation of dose while achieving a therapeutic level in a clinically effective period of time. The methods can comprise the steps of clearance, escalation, and maintenance. In one embodiment the dosing regimen administers an initial (i) sub-therapeutic dose of an anti-CD47 agent or (ii) a cytoreductive therapy to achieve a safe level of circulating tumor cells for subsequent treatment (clearance); escalating the dose of an anti-CD47 agent until a therapeutic dose is reached (escalation); and maintaining the therapeutic dose for a period of time sufficient to reduce tumor cells in the bone marrow of the patient (maintenance). In an alternative dosing regimen, a patient determined to have a safe level of circulating tumor cells at presentation is treated by the steps of escalation and maintenance without initial clearance.

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Patent Owner(s)

Patent OwnerAddress
FORTY SEVEN LLC333 LAKESIDE DRIVE FOSTER CITY CA 94404

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chao, Mark Ping Palo Alto, US 10 4
Liu, Jie Palo Alto, US 812 14130
Majeti, Ravindra Palo Alto, US 70 778
Volkmer, Jens-Peter Menlo Park, US 43 216
Weissman, Irving L Stanford, US 185 2200

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