FAK inhibitor and drug combination thereof

Number of patents in Portfolio can not be more than 2000

United States of America

PATENT NO 12194040
APP PUB NO 20220125788A1
SERIAL NO

17418678

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Abstract

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A deuterated compound as represented by formula (I) or an optical isomer, a tautomer, a pharmaceutically acceptable salt, a prodrug, a hydrate, or a solvate thereof are presented. Compared with a compound before deuteration, the deuterated compound shows better pharmacokinetics, higher maximum plasma drug concentration, higher exposure, and longer half-life, and has more excellent metabolic performance. The deuterated compound can effectively inhibit FAK activity, and has good application prospect in preparation of FAK inhibitors and/or drugs for treating cancer. In addition, the use of the deuterated compound in combination with an anti-cancer drug (such as a PD-1 inhibitor) can achieve a synergistic effect, thereby significantly improving the tumor suppression effect, and providing a better choice for clinical cancer treatment.

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Patent Owner(s)

Patent OwnerAddress
HINOVA PHARMACEUTICALS INCNO 1 4RD FLOOR RONGYAO BUILDING A 5 KEYUAN SOUTH ROAD HIGH-TECH ZONE CHENGDU SICHUAN 610041 610041

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chen, Yuanwei Sichuan, CN 44 541
Du, Wu Sichuan, CN 29 43
Li, Xinghai Sichuan, CN 47 254
Li, Yu Sichuan, CN 376 3295
Wen, Kun Sichuan, CN 8 0

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