Multi-stage, multiplexed target isolation and processing from heterogeneous populations

Number of patents in Portfolio can not be more than 2000

United States of America

PATENT NO 12188925
APP PUB NO 20220034869A1
SERIAL NO

17163054

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Abstract

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A system and method for isolating target substrates includes a microfluidic chip, comprising a plurality of processing units, each processing unit comprising: an inlet port, a plurality of first chambers connected to the inlet port by a fluid channel, the fluid channel comprising a plurality of valves, a plurality of second chambers, each of the second chambers connected to a respective first chamber by a fluid channel, each fluid channel including a controllable blocking valve, and a plurality of respective outlet ports, each outlet port in fluid communication with a respective one of said second chambers and each outlet port including a blocking valve. A magnet is adjacent the microfluidic chip and is movable relative to the microfluidic chip. A valve control is capable of actuating certain ones of the controllable blocking valves in response to a control signal.

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Patent Owner(s)

Patent OwnerAddress
THE GENERAL HOSPITAL CORPORATION55 FRUIT STREET BOSTON MA 02114

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Blainey, Paul Cambridge, US 46 397
Hacohen, Nir Brookline, US 64 734
Vickers, Dwayne San Diego, US 2 10

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