Type-II VNAR polypeptides which bind human TfR-1, encoding nucleic acids thereof and method of use thereof

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United States of America

PATENT NO 12187805
APP PUB NO 20240026022A1
SERIAL NO

18033600

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Abstract

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The present invention relates to a high affinity, VNAR polypeptide cross reactive with primate transferrin receptors (“TfR”). This TfR-specific VNAR polypeptide was obtained by screening semisynthetic VNAR phage display libraries against recombinant human TfR-1. The VNAR polypeptides of the invention can be used alone or as a component in conjugates that target the transferrin/transferrin receptor transport system. The invention further includes use of this VNAR, its conjugates and other derivatives in diagnostic and therapeutic methods, e.g., to diagnose, treat and/or prevent a pathological condition, disorder or disease in which it is beneficial to deliver a heterologous biomolecule across the blood brain barrier or other membrane systems. This TfR-specific VNAR polypeptide can also be used to target other biological barriers such the intestines, the placenta or aberrant cells overexpressing TfR-1, for therapeutic benefit in treatment of certain cancer cells and tumors of various tissue types. Deimmunized VNAR scaffolds are also provided.

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Patent OwnerAddress
OSSIANIX INC3711 MARKET ST PHILADELPHIA PA 19104

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Coker, Shu-Fen Amersham, GB 2 0
Demydchuk, Mykhaylo Cambridge, GB 5 4
Rutkowski, Julia Lynn Bryn Mawr, US 17 64
Stocki, Pawel Hertfordshire, GB 11 7
Szary, Jaroslaw Michal Cambridge, GB 9 5
Thei, Laura Cambridge, GB 2 0
Wicher, Krzysztof Bartlomiej Cambridge, GB 10 45

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