Preparation of conserved homology 1 domains complexed to ligands
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United States of America
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Jan 7, 2025
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Mar 2, 2023
app pub date -
Aug 31, 2022
filing date -
Aug 31, 2022
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Abstract
A crystallization method for making high-quality molecular crystals containing complexes of diacylglycerol (DAG)-effector proteins and ligands thereof. For example, some of such crystals are of a quality sufficient for crystal-structure determination by X-ray crystallography with a spatial resolution of at least 3.0 Å or, in some cases, of about 1 Å. At least some embodiments of the crystallization method and of the molecular crystals produced thereby can beneficially be used, e.g., to provide high-resolution guides for the design and development of exogenous agonists of DAG-effector proteins of therapeutic interest.
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