Polymer materials for delivery of short-chain fatty acids to the intestine for applications in human health and treatment of disease
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United States of America
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Jan 7, 2025
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Sep 21, 2023
app pub date -
Apr 19, 2023
filing date -
Apr 19, 2023
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Abstract
Provided herein are polymer materials that find use in, for example, delivery of short-chain fatty acids. In particular, polymers are provided that form stable nanoscale structures and release their payload, for example, by cleavage of a covalent bond (e.g., via hydrolysis or enzymatic cleavage). The polymers are useful, for example, for delivery of payloads (e.g., SCFAs) to the intestine for applications in health and treatment of disease, and have broad applicability in diseases linked to changes in the human microbiota including inflammatory, autoimmune, allergic, metabolic, and central nervous system diseases, among others.
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