Cocaine esterase mutant and use thereof

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United States of America

PATENT NO 12180519
APP PUB NO 20240117329A1
SERIAL NO

18489816

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Abstract

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Disclosed are a cocaine esterase mutant and use thereof. The cocaine esterase mutant is obtained by mutating a wildtype cocaine esterase, an amino acid sequence of the wildtype cocaine esterase is shown as SEQ ID No. 1, the cocaine esterase mutant is T172R/G173Q/L196C/I301C, or additionally added with V116K point mutation, or additionally added with A51 site mutation, and the A51 site mutation is L, Y, V, F or W. Catalytic efficiency of the cocaine esterase mutant screened on a cocaine toxic metabolite benzoylecgonine is greatly improved compared with that of a wildtype enzyme.

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Patent Owner(s)

Patent OwnerAddress
HANGZHOU NORMAL UNIVERSITY2318 YUHANGTANG ROAD CANGQIAN STREET YUHANG DISTRICT HANGZHOU CITY ZHEJIANG PROVINCE HANGZHOU CITY ZHEJIANG PROVINCE 311121

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chen, Xiabin Hangzhou, CN 3 0
Deng, Xingyu Hangzhou, CN 4 0
Hou, Shurong Hangzhou, CN 5 0
Tong, Junsen Hangzhou, CN 1 0
Yao, Jianzhuang Hangzhou, CN 1 0
Zhang, Yun Hangzhou, CN 273 1506

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