Nucleic acid-tagged compositions and methods for multiplexed protein-protein interaction profiling

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United States of America

PATENT NO 12180467
APP PUB NO 20240011019A1
SERIAL NO

18348201

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Abstract

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Methods and compositions for multiplexed protein-protein interaction profiling (e.g., immunoprofiling), based on nucleic acid tagging of polypeptides (e.g., by RNA display) are described. In some embodiments the described compositions and methods utilize a library of prey polypeptide targets linked to prey RNAs encoding them, and a population of bait polypeptides, e.g., a mixture of antibodies, that bind to one or more of the prey polypeptide targets and are used to isolate and identify the bound prey polypeptide targets by amplification of their associated prey RNAs and sequencing of the corresponding cDNAs. In other embodiments the prey polypeptide targets are linked to DNA Bar Codes, which serve as unique identifiers of the tagged polypeptide.

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Patent Owner(s)

Patent OwnerAddress
ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY1475 NORTH SCOTTSDALE ROAD SKYSONG - SUITE 200 SCOTTSDALE AS 85257-9908

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
LaBaer, Joshua Chandler, US 72 1244

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