Compositions and methods for selective labeling of secondary amines
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United States of America
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Dec 31, 2024
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Sep 21, 2022
filing date -
Sep 21, 2022
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Abstract
This disclosure relates to compositions and methods for selective labeling of N-alkyl lysine, N-alkyl adenosine, proline, N-alkyl cytosine, peptides, nucleic acids, or aliphatic or aromatic secondary amines. In certain embodiments, this disclosure relates to methods of forming triazene labeled compounds comprising contacting a compound containing a secondary amine group with a compound comprising an aromatic group with a diazonium para substituted with an electron rich group under conditions such that a triazene labeled compound is formed at the secondary amine group.
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