High concentration formulations of anti-CSF1 and anti-CSF1R antibodies

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United States of America

PATENT NO 12178915
APP PUB NO 20220370364A1
SERIAL NO

17747844

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Abstract

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Provided are high concentration stable formulations of anti-CSF1R/CSF1 antibodies. An example formulation includes 105 to 250 mg/mL of the antibody, 100 mM to 200 mM of arginine glutamate or arginine HCl, 10 mM to 50 mM histidine, and 0.015 to 0.035 w/v % of polysorbate 80, at a pH of 5.4 to 5.6. Also provided are methods of using the formulations for treating diseases.

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Patent Owner(s)

Patent OwnerAddress
AMMAX BIO INC555 TWIN DOLPHIN DRIVE SUITE 610 REDWOOD CITY CA 94065

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Alani, Laman Menlo Park, US 44 294
Hsu, Chung-Chiang Los Altos Hills, US 12 61
Huang, Michael Ladera Ranch, US 62 1596
Johnson, Kirk William Moraga, US 17 45
Zhu, Aihua Foster City, US 8 24

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