Methods and compositions for the treatment of exocrine pancreatic insufficiency

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United States of America

PATENT NO 12178848
APP PUB NO 20220257716A1
SERIAL NO

17693057

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Abstract

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The present invention relates to the treatment of secretory disorders, and provides novel methods of treatment of these disorders comprising the administration of fibroblast growth factor 21 (FGF21) or derivatives thereof. The methods of the invention are useful in conditions including exocrine pancreatic insufficiency (EPI), for example EPI resulting from cystic fibrosis, alcoholism, pancreatitis, pancreatic cancer, gallstones, celiac disease, high triglycerides, or lupus. The methods of the present invention find further utility in the treatment of salivary flow disorders, for example Sjorgen's syndrome, and the treatment of EPI or pancreatitis resulting from surgical procedures.

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Patent Owner(s)

Patent OwnerAddress
BOARD OF REGENTS THE UNIVERSITY OF TEXAS SYSTEMAUSTIN TX 78701

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Coate, Katie C Pelham, US 2 0
Hernandez, Genaro Dallas, US 2 0
Kliewer, Steven A Dallas, US 11 107
Mangelsdorf, David J Dallas, US 21 283

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