System and method for characterizing protein dimerization
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United States of America
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Dec 24, 2024
Grant Date -
Apr 13, 2023
app pub date -
Nov 2, 2022
filing date -
Nov 2, 2022
priority date (Note) -
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Abstract
Systems and methods to characterize dimerization interfaces at the subdomain level of a protein are provided. An exemplary method includes digesting a protein dimer sample into subdomains, labeling the digested protein sample, isolating labeled dimeric and monomeric subdomain fragments, and peptide mapping the labeled sample to determine where the dimer fragments are labeled and where the dimer fragments are not labeled. Regions that show decreased labeling extents in the dimer fraction than that in the monomer fraction are likely involved or in close proximity to the dimerization interface.
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International Classification(s)
- 2022 Application Filing Year
- A61K Class
- 20288 Applications Filed
- 3818 Patents Issued To-Date
- 18.82 % Issued To-Date
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