Melanocortin 1 receptor ligands and methods of use

Number of patents in Portfolio can not be more than 2000

United States of America

PATENT NO 12173087
APP PUB NO 20230167154A1
SERIAL NO

17582368

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Abstract

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The subject invention pertains to a modified MC1R peptide ligand comprising a peptide that is a melanocortin 1 receptor (MC1R) ligand and a functionality or linker, such as a click functionality, for conjugation to a surface or agent. The modified MC1R peptide ligand can be coupled, e.g., via a click reaction with a complementary click functionality attached, to a moiety to form an MC1R-targeted agent. Drugs, contrast agents, polymers, particles, micelles, surfaces of larger structures, or other moieties can be targeted to the MC1R. The subject invention also pertains to a MC1R peptide ligand-micelle complex comprising a peptide that is a melanocortin 1 receptor ligand connected via a click reaction product to a micelle. The micelle is stable in vivo and can target melanoma tumor cells by association of the peptide ligand with the MC1R or the tumor and selectively provide a detectable and/or therapeutic agent (such as an imagable contrast agent and/or anti-cancer agent) selectively to the tumor cell.

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Patent Owner(s)

  • H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE INC.; INTEZYNE TECHNOLOGIES INC.; THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA; 501 BOARD OF REGENTS THE UNIVERSITY OF TEXAS SYSTEM

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Barkey, Natalie M Tampa, US 4 12
Gillies, Robert J Tampa, US 23 399
Hruby, Victor J Tucson, US 44 640
Morse, David L Tampa, US 44 751
Preihs, Christian Austin, US 6 17
Sessler, Jonathan L Austin, US 94 2801
Sill, Kevin N Tampa, US 55 819
Tafreshi, Narges K Tampa, US 5 16
Vagner, Josef Tucson, US 24 114

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