Prevention of disulfide bond reduction during recombinant production of polypeptides

Number of patents in Portfolio can not be more than 2000

United States of America

PATENT NO 12173080
SERIAL NO

18824681

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Abstract

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The invention concerns methods for preventing the reduction of disulfide bonds during the recombinant production of disulfide-containing polypeptides. In particular, the invention concerns the prevention of disulfide bond reduction during harvesting of disulfide-containing polypeptides, including antibodies, from recombinant host cell cultures.

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Patent Owner(s)

Patent OwnerAddress
GENENTECH INCSOUTH SAN FRANCISCO CA 94080

International Classification(s)

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  • 2024 Application Filing Year
  • A61K Class
  • 9279 Applications Filed
  • 536 Patents Issued To-Date
  • 5.78 % Issued To-Date
Click to zoom InYear of Issuance% of Matters IssuedCumulative IssuancesYearly Issuances202420250255075100

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hewitt, Daniel P Sunnyvale, US 16 253
Kao, Yung-Hsiang San Mateo, US 27 637
Laird, Michael W San Ramon, US 41 488
Schmidt, Melody Trexler Danville, US 16 253
Wong, Rita L Redwood City, US 23 909

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Citation count rangeNumber of patents cited in rangeNumber of patents cited in various citation count ranges26596611201 - 1011 - 200200040006000800010000120001400016000180002000022000240002600028000

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