PRMT5 inhibitors

Number of patents in Portfolio can not be more than 2000

United States of America

PATENT NO 12173026
APP PUB NO 20220363707A1
SERIAL NO

17266521

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Abstract

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The present invention provides a compound of Formula (I) and the pharmaceutically acceptable salts, esters, and prodrugs thereof, which are PRMT5 inhibitors. Also provided are methods of making compounds of Formula I, pharmaceutical compositions comprising compounds of Formula I, and methods of using these compounds to treat cancer, sickle cell, and hereditary persistence of foetal hemoglobin (HPFH) mutations.

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Patent Owner(s)

Patent OwnerAddress
MERCK SHARP & DOHME LLC126 EAST LINCOLN AVENUE RAHWAY NJ 07065

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Candito, David A Wrentham, US 5 0
Fier, Patrick S Monroe Township, US 3 0
Gibeau, Craig Northborough, US 6 7
Henderson, Timothy J Beaulieu, US 22 95
Huang, Chunhui Arlington, US 16 16
Hughes, Jonathan M E Hoboken, US 1 0
Kawamura, Shuhei Cambridge, US 12 11
Machacek, Michelle Belmont, US 18 34
Paparin, Jean-Laurent Vendemian, FR 25 224
Quiroz, Ryan Boston, US 8 1
Rahali, Houcine Beaulieu, FR 13 273
Reutershan, Michael H Brighton, US 18 172
Sanyal, Sulagna Belmont, US 5 1
Schneider, Sebastian Boston, US 25 29
Siliphaivanh, Phieng Newton, US 46 160
Silverman, Steven M Jersey City, US 4 20
Sloman, David L Brookline, US 37 147
Wan, Murray Watertown, US 6 0
Witter, David Norfolk, US 15 72
Ye, Yingchun Belmont, US 16 48
Yeung, Charles S Dedham, US 8 0

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