Yeast expressing saccharolytic enzymes for consolidated bioprocessing using starch and cellulose

Number of patents in Portfolio can not be more than 2000

United States of America

PATENT NO 12168768
SERIAL NO

17500501

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Abstract

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The present invention is directed to a yeast strain, or strains, secreting a full suite, or any subset of that full suite, of enzymes to hydrolyze corn starch, corn fiber, lignocellulose, (including enzymes that hydrolyze linkages in cellulose, hemicellulose, and between lignin and carbohydrates) and to utilize pentose sugars (xylose and arabinose). The invention is also directed to the set of proteins that are well expressed in yeast for each category of enzymatic activity. The resulting strain, or strains can be used to hydrolyze starch and cellulose simultaneously. The resulting strain, or strains can be also metabolically engineered to produce less glycerol and uptake acetate. The resulting strain, or strains can also be used to produce ethanol from granular starch without liquefaction. The resulting strain, or strains, can be further used to reduce the amount of external enzyme needed to hydrolyze a biomass feedstock during an Simultaneous Saccharification and Fermentation (SSF) process, or to increase the yield of ethanol during SSF at current saccharolytic enzyme loadings. In addition, multiple enzymes of the present invention can be co-expressed in cells of the invention to provide synergistic digestive action on biomass feedstock. In some aspects, host cells expressing different heterologous saccharolytic enzymes can also be co-cultured together and used to produce ethanol from biomass feedstock.

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Patent Owner(s)

Patent OwnerAddress
DANSTAR FERMENT AGPOSTSTRASSE 30 ZUG 6300

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Agbogbo, Frank Lebanon, US 8 84
Argyros, Aaron White River Junction, US 62 157
Bardsley, John S Newport, US 8 60
Barrett, Trisha Bradford, US 37 127
Belcher, Alan Nashua, US 9 79
Brevnova, Elena Lebanon, US 21 123
Caiazza, Nicky Rancho Santa Fe, US 23 244
Chiu, Yin-Ying West Lebanon, US 6 58
Deleault, Kristen M Canaan, US 7 58
Den, Haan Riaan Vierlanden, ZA 16 95
Foster, Abigail South Strafford, US 5 29
Froehlich, Allan C Lebanon, US 11 104
Gandhi, Chhayal V Lebanon, US 6 58
Gosselin, Jennifer Lebanon, US 6 58
Hau, Heidi Lebanon, US 7 49
McBride, John E Lyme, US 11 85
Mellon, Mark Grantham, US 25 368
Rajgarhia, Vineet B Courbevoie, FR 7 66
Rice, Charles F Hopkinton, US 24 74
Shikhare, Indraneel Lebanon, US 7 59
Skinner, Ryan White River Junction, US 19 70
Stonehouse, Emily Lebanon, US 12 66
Tripathi, Shital A Berkeley, US 13 86
Warner, Anne K Lebanon, US 8 65
Wenger, Kevin S Hanover, US 15 153
Wiswall, Erin Danbury, US 18 119
Xu, Haowen Lebanon, US 27 136

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