Genetically encoded polypeptide for affinity capture and purification of biologics
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United States of America
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Dec 10, 2024
Grant Date -
Jan 4, 2024
app pub date -
Jul 3, 2023
filing date -
Jul 3, 2023
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Abstract
The invention relates to genetically encoded fusion proteins comprised of a capture component that binds a target with high affinity and a peptide polymer, such as elastin-like polypeptides, that display phase behavior and can be used for purification. The invention further relates to methods for optimizing capture fusion proteins for individual biologic targets such that phase separation occurs under desirable conditions, such as at room temperature, lower concentrations of salt, and/or at suitable pH ranges and optimized capture domains and polypeptides with phase behavior that have been identified by the optimization methods.
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