Microneedle-array patches with glucose-responsive matrix for closed-loop insulin delivery

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United States of America

PATENT NO 12161749
APP PUB NO 20210244658A1
SERIAL NO

17270953

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Abstract

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Disclosed are compositions and methods for microneedle patches comprising copolymer designed for glucose triggered insulin delivery. In one aspect, disclosed herein are microneedle patches comprising insulin loaded copolymers; wherein the insulin dissociates from the microneedle in an hyperglycemic environment; wherein the copolymer comprises poly(N-vinylpyrrolidone-co-2-N(dimethylamino)ethyl acrylate-co-3-(acrylamido)phenylboronic acid and methods of their use.

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Patent Owner(s)

Patent OwnerAddress
NORTH CAROLINA STATE UNIVERSITY1021 MAIN CAMPUS DRIVE 2ND FLOOR RALEIGH NC 27606

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chen, Guojun Raleigh, US 40 91
Gu, Zhen Los Angeles, US 88 100
Yu, Jicheng Raleigh, US 9 5

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