Processes for the formulation of pneumococcal polysaccharides for conjugation to a carrier protein

Number of patents in Portfolio can not be more than 2000

United States of America

PATENT NO 12161721
APP PUB NO 20220296723A1
SERIAL NO

17806107

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Abstract

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The present invention provides a number of process improvements related to the conjugation of capsular polysaccharides from Streptococcus pneumoniae to a carrier protein. These process are serotype specific and include acid hydrolysis, addition of sodium chloride to the reductive amination reaction, and addition of sucrose to dissolve polysaccharides. Polysaccharide-protein conjugates prepared using the processes of the invention can be included in multivalent pneumococcal conjugate vaccines.

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Patent Owner(s)

  • MERCK SHARP & DOHME LLC

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Konietzko, Janelle Lansdale, US 7 53
McHugh, Patrick Pipersville, US 24 326
Winters, Michael Albert Doylestown, US 17 84

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