Target-specific extracellular vesicles

Number of patents in Portfolio can not be more than 2000

United States of America

PATENT NO 12146238
APP PUB NO 20210395725A1
SERIAL NO

17268909

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Abstract

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Provided herein is a method of producing a protein comprising a target-specific extravesicular domain (TED) of an extracellular vesicle (EV) surface protein comprising modifying a polynucleotide comprising a nucleotide sequence encoding the extravesicular domain (ED) of an EV surface protein by a mutagenesis method within at least one modified region within the ED amino acid sequence with a length of 3-20 contiguous amino acids flanked by regions of the wild-type ED sequence at its N-terminus and C-terminus, to incorporate a target binding site within the ED, thereby producing a repertoire of polynucleotides encoding a variety of TEDs, each comprising a different target binding site, and selecting a TED specifically recognizing a predetermined target, and producing the protein comprising the selected TED.

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Patent Owner(s)

Patent OwnerAddress
UNIVERSITAT FUR BODENKULTUR WIENGREGOR-MENDEL-STRASSE 33 WIEN 1180

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bobbili, Madhusudhan Reddy Vienna, AT 1 0
Grillari, Johannes Bisamberg, AT 13 15
Rueker, Florian Vienna, AT 1 0
Stadlmayr, Gerhard Vienna, AT 4 2
Vogt, Stefan Vienna, AT 3 32
Wozniak-Knopp, Gordana Vienna, AT 22 218

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