Compound and a method for identifying a protein using said compound
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United States of America
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Nov 19, 2024
Grant Date -
Dec 23, 2021
app pub date -
Jun 17, 2021
filing date -
Jun 17, 2021
priority date (Note) -
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Abstract
The present invention relates to a compound for use in detecting “reader” and “eraser” proteins of lysine lipoylation. The present invention provides an affinity-based probe, referred to herein as “KPlip”, capable of interrogating the lipoylated peptide/protein interactions under native cellular environments. The chemical probe allows for the identification of potential regulators of lysine lipoylation, thus uncovering new biology related to lipoylation. There is also provided a method of using the compound to identifying proteins that interact with lipoylated proteins.
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