Recombinant HIV-1 envelope proteins and their use

Number of patents in Portfolio can not be more than 2000

United States of America

PATENT NO 12145968
APP PUB NO 20230227512A1
SERIAL NO

17937719

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Abstract

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HIV-1 Env ectodomain trimers stabilized in a prefusion mature closed conformation and methods of their use and production are disclosed. In several embodiments, the HIV-1 Env ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to HIV-1 in a subject. In additional embodiments, the therapeutically effective amount of the HIV-1 Env ectodomain trimers can be administered to a subject in a method of treating or preventing HIV-1 infection.

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Patent Owner(s)

Patent OwnerAddress
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY DEPARTMENT OF HEALTH AND HUMAN SERVICES6011 EXECUTIVE BOULEVARD SUITE 325 MSC 7660 OFFICE OF TECHNOLOGY TRANSFER NATIONAL INSTITUTES OF HEALTH BETHESDA MD 20892-7660

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Acharya, Priyamvada Chapel Hill, US 6 23
Chen, Rita St. Louis, US 19 515
Cheng, Cheng Bethesda, US 86 192
Chuang, Gwo-Yu Rockville, US 23 84
Druz, Aliaksandr Germantown, US 12 31
Georgiev, Ivelin Nashville, US 19 43
Gorman, Jason Washington, US 14 123
Joyce, Michael Gordon Washington, US 33 195
Kwong, Peter Washington, US 55 200
Mascola, John Rockville, US 51 109
Pancera, Marie Seattle, US 17 112
Sastry, Mallika Rockville, US 10 53
Stewart-Jones, Guillaume Cambridge, US 36 160
Yang, Yongping Potomac, US 33 106
Zhang, Baoshan Bethesda, US 35 163
Zhou, Tongqing Boyds, US 44 202

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