Biomedical patches with aligned fibers

Number of patents in Portfolio can not be more than 2000

United States of America

PATENT NO 12144716
APP PUB NO 20210338408A1
SERIAL NO

17358463

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Importance

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Abstract

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A multi-laminar electrospun nanofiber scaffold for use in repairing a defect in a tissue substrate is provided. The scaffold includes a first layer formed by a first plurality of electrospun polymeric fibers, and a second layer formed by a second plurality of electrospun polymeric fibers. The second layer is combined with the first layer. A first portion of the scaffold includes a higher density of fibers than a second portion of the scaffold, and the first portion has a higher tensile strength than the second portion. The scaffold is configured to degrade via hydrolysis after at least one of a predetermined time or an environmental condition. The scaffold is configured to be applied to the tissue substrate containing the defect, and is sufficiently flexible to facilitate application of the scaffold to uneven surfaces of the tissue substrate, and to enable movement of the scaffold by the tissue substrate.

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Patent Owner(s)

Patent OwnerAddress
WASHINGTON UNIVERSITYONE BROOKINGS DRIVE SAINT LOUIS MO 63130

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
MacEwan, Matthew R St. Louis, US 34 549
Ray, Zack St. Louis, US 11 279
Xia, Younan St. Louis, US 56 2287
Xie, Jingwei St. Louis, US 37 370

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