Mobilisation of transposable elements to enhance genetic and epigenetic variability in a population
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United States of America
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Nov 19, 2024
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Dec 13, 2018
app pub date -
Nov 30, 2016
filing date -
Nov 30, 2016
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Abstract
A method for the mobilization of a transposable element is provided. The method comprises the steps of a) providing an inhibitor of DNA methylation, and/or an inhibitor of transcription, and b) contacting the inhibitor(s) with a cell comprising inactivated transposable elements, yielding a cell with mobilized transposable elements. In a second aspect of the invention a method for increasing the genetic and/or epigenetic variation in a plurality of eukaryotic organisms is provided. The method comprises the steps of i. providing an inhibitor of DNA methylation and/or an inhibitor of transcription, ii. contacting the organism with the inhibitor(s) and iii. propagating the organism.
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