Deep learning enabled spatial optical barcodes for pooled library screens

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United States of America

PATENT NO 12139705
APP PUB NO 20210130810A1
SERIAL NO

17088594

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Abstract

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Disclosed herein include systems, methods, and compositions for determining perturbations in single cells or performing integrated measurements using, for example, plasmids each comprising (i) a perturbation gRNA with a guide region targeting a chromosome sequence and (ii) barcode gRNAs each with a guide region targeting predetermined spatial region of the genome and zero, one, or more optical detection probe binding sites.

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Patent Owner(s)

Patent OwnerAddress
CALIFORNIA INSTITUTE OF TECHNOLOGY1200 E CALIFORNIA BOULEVARD PASADENA CA 91125

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Pao, Edward San Dimas, US 4 31
Schwartz, Morgan S Pasadena, US 1 0
Van, Valen David A Pasadena, US 4 7

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