Antibody that binds ErbB-2 and ErbB-3

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United States of America

PATENT NO 12139548
APP PUB NO 20230242669A1
SERIAL NO

18047933

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Abstract

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The invention relates among others to antibodies comprising a first antigen-binding site that binds Erb B-2 and a second antigen-binding site that binds Erb B-3. The antibodies can typically reduce a ligand-induced receptor function of Erb B-3 on a Erb B-2 and Erb B-3 positive cell. Also described are method for the treatment and use of the antibodies in imaging and in the treatment of subjects having an Erb B-2, Erb B-3 or Erb B-2/3 positive tumor.

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Patent Owner(s)

  • MERUS N.V.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bakker, Alexander Berthold Hendrik Utrecht, NL 28 460
De, Kruif Cornelis Adriaan Utrecht, NL 64 1374
Geuijen, Cecilia Anna Wilhelmina Utrecht, NL 26 97
Logtenberg, Ton Utrecht, NL 96 2507
Throsby, Mark Utrecht, NL 72 1481

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