Extruded hydrogel tubes and coaxial fibers and applications thereof

Number of patents in Portfolio can not be more than 2000

United States of America

PATENT NO 12138843
APP PUB NO 20210114276A1
SERIAL NO

17251735

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Abstract

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Methods of fabricating a hydrogel tube, and related systems, employ extrusion of a cross-linkable hydrogel solution from an annular outer nozzle of a nozzle assembly to form a cross-linkable hydrogel tube. The cross-linkable hydrogel tube is cured to form a cross-linked hydrogel tube. A second hydrogel solution can be coextruded via the axial inner nozzle to form an inner hydrogel filament coaxially positioned within the cross-linkable hydrogel tube. The cross-linked hydrogel tube can be functionalized with collagen to enable cell adhesion, and cells can be cultured on the luminal surfaces of these tubes to yield tubular endothelial layers. A 3D printed coaxial nozzle can be used to fabricate biofunctional tubular conduits that can be utilized for engineering in vitro models of tubular biological structures.

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Patent Owner(s)

Patent OwnerAddress
UNIVERSITY OF WASHINGTONOFFICE OF TECHNOLOGY TRANSFER SUITE 301 4225 ROOSEVELT WAY N E SEATTLE WA 98105

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Dostie, Ashley Seattle, US 1 5
Karis, Dylan Seattle, US 2 5
Millik, Siyami Seattle, US 2 5
Nelson, Alshakim Seattle, US 55 648
Smith, Patrick Seattle, US 120 2024
Theberge, Ashleigh Seattle, US 3 7

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