Cape-loaded targeted microvesicular cancer drug and method for developing the same

Number of patents in Portfolio can not be more than 2000

United States of America

PATENT NO 12138235
APP PUB NO 20220362194A1
SERIAL NO

17840700

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Abstract

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A method of producing a caffeic acid phenethyl ester loaded microvesicular cancer drug targeting SH-SY5Y neuroblastoma cancer. The method includes seeding a plurality of skin stem cells in a medium; enabling the plurality of skin stem cells in the medium to reach a confluency of 70-80% to be seeded in a plurality of culture plates; preparing a caffeic acid phenethyl ester stock solution by dissolving the caffeic acid phenethyl ester in dimethyl sulfoxide DMSO; performing a microvesicle isolation from specialized skin cells; adding the caffeic acid phenethyl ester into a plurality of microvesicles; and separating the caffeic acid phenethyl ester loaded microvesicles from the caffeic acid phenethyl ester which is free in the solution and not loaded to a microvesicle.

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YEDITEPE UNIVERSITESI34755 ISTANBUL

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Apdik, Huseyin Istanbul, TR 2 1
Avsar, Apdik Ezgi Istanbul, TR 3 1
Kirbas, Oguz Kaan Istanbul, TR 12 1
Sahin, Fikrettin Istanbul, TR 47 34
Tasli, Pakize Neslihan Istanbul, TR 14 1

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