Articles and methods involving detection of binding

Number of patents in Portfolio can not be more than 2000

United States of America

PATENT NO 12135330
APP PUB NO 20200018769A1
SERIAL NO

16497485

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Abstract

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Articles and methods involving detection of binding between two or more species using MALDI are generally provided. In some embodiments, a method comprises exposing a first species to a composition comprising a second species, capturing the first species on a self-assembled monolayer, and performing MALDI on the self-assembled monolayer to generate a signal from the second species and a signal from a standard species present in the self-assembled monolayer. A ratio (first ratio) of the signal from the second species to the signal from the standard species may be compared to a cutoff value in order to determine if binding has occurred. This method may allow determination of a relative affinity of the second species for the first species.

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Patent Owner(s)

  • CHARLES RIVER LABORATORIES INTERNATIONAL, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Scholle, Michael D Bolingbrook, US 12 441
Sherrill, John San Diego, US 4 11

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