Use of PAYCS in regulation of intestinal flora, metabolites, and brain neurotransmitters

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United States of America

PATENT NO 12128084
APP PUB NO 20230330177A1
SERIAL NO

18170163

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The present disclosure belongs to the technical field of health food, and in particular, relates to the use of PAYCS in the regulation of intestinal flora, metabolites, and brain neurotransmitters. PAYCS remedies scopolamine-induced memory impairment in mice through target oxidation, inflammatory stress and regulation of the intestinal microorganism-metabolite-brain neurotransmitter axis through PAYCS. PAYCS improves the memory pathway through the intestinal microorganism-metabolite-neurotransmitter axis. PAYCS can significantly reduce serum MDA and LDH levels and significantly increase liver SOD content. PAYCS-H inhibits the increase of liver TNF-α and IL-1β, while PAYCS-L can only reduce the content of TNF-α in the liver. Thus, PAYCS-L changes the ratio of Bacteroides/Firmicutes and increases the relative abundance of plants such as Cactaceae and Prevotellaceae, improving the neurotransmitters associated with the metabolism of tryptophan in the brain.

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Patent Owner(s)

Patent OwnerAddress
SERICULTURE AND AGRI-FOOD RESEARCH INSTITUTE GUANGDONG ACADEMY OF AGRICULTURAL SCIENCES133 YIHENG ROAD GUANGZHOU 510610

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chen, Shuai Guangzhou, CN 191 403
Jiao, Wenjuan Guangzhou, CN 3 25
Liu, Weifeng Guangzhou, CN 125 686
Zhang, Yehui Guangzhou, CN 9 119
Zhang, Yousheng Guangzhou, CN 2 0
Zhao, Tiantian Guangzhou, CN 6 0

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