Humanized M-CSF mice

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United States of America

PATENT NO 12127536
APP PUB NO 20210112791A1
SERIAL NO

17000105

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Abstract

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Genetically modified mice comprising a nucleic acid sequence encoding a human M-CSF protein are provided. Also provided are genetically modified mice comprising a nucleic acid sequence encoding a human M-CSF protein that have been engrafted with human cells such as human hematopoietic cells, and methods for making such engrafted mice. These mice find use in a number of applications, such as in modeling human immune disease and pathogen infection; in in vivo screens for agents that modulate hematopoietic cell development and/or activity, e.g. in a healthy or a diseased state; in in vivo screens for agents that are toxic to hematopoietic cells; in in vivo screens for agents that prevent against, mitigate, or reverse the toxic effects of toxic agents on hematopoietic cells; in in vivo screens of human hematopoietic cells from an individual to predict the responsiveness of an individual to a disease therapy, etc.

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Patent Owner(s)

Patent OwnerAddress
REGENERON PHARMACEUTICALS INC777 OLD SAW MILL RIVER ROAD TARRYTOWN NY 10591

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Eynon, Elizabeth New Haven, US 14 379
Flavell, Richard Guilford, US 42 602
Manz, Markus Zollikon, CH 23 444
Murphy, Andrew J Croton-on-Hudson, US 509 7038
Rathinam, Chozhavendan Yonkers, US 5 110
Stevens, Sean San Diego, US 219 3937
Yancopoulos, George D Yorktown Heights, US 248 6261

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