Related substance of linagliptin intermediate and synthesis method thereof

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 12122754
APP PUB NO 20230010367A1
SERIAL NO

17433618

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Abstract

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A related substance of linagliptin intermediate 2-(chloromethyl)-4-methylquinazoline, 4,4′-(2-methylpropane-1,3-diyl)bis(2-(chloromethyl)quinazoline) and a method for synthesizing the related substance (impurity) by reacting 2-(chloromethyl)-4-methylquinazoline with acetaldehyde under an alkaline condition and a purification method are provided. The preparation method is simple and convenient to operate, short in reaction time, high in product purity, and high in yield. The synthesized related substance can be used for qualitative and quantitative analysis of the linagliptin intermediate 2-(chloromethyl)-4-methylquinazoline and API impurities of linagliptin, so that the medication safety of the linagliptin is improved.

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Patent Owner(s)

Patent OwnerAddress
WISDOM PHARMACEUTICAL CO LTDNO 18 QINGHUA ROAD SANCHANG STREET HAIMEN DISTRICT NANTONG JIANGSU 226123 226123

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chu, Lingling Nantong, CN 5 0
Hu, Lin Nantong, CN 65 344
Liu, Wenbo Nantong, CN 70 104
Qiu, Xiaolong Nantong, CN 9 4
Wang, Hu Nantong, CN 70 222
Xu, Tao Nantong, CN 336 2428
Zou, Ping Nantong, CN 28 182
Zuo, Zhiwei Nantong, CN 7 0

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