Blood coagulation-promoting silk fibroin-polypeptide electrospun membrane and preparation method thereof

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United States of America Patent

PATENT NO 12121626
SERIAL NO

17542473

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Abstract

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The present invention discloses a blood coagulation-promoting silk fibroin-polypeptide electrospun membrane and a preparation method thereof. The electrospun membrane is made by using silkworm silk fibroin as a carrier and adding the polypeptide GPRPPSEHLQIT. It is mainly used for promoting blood coagulation, and is a blood coagulation material that can targetedly bind to human fibrinogen. The preparation method includes the steps of dissolving, filtering, dialyzing, concentrating and freeze-drying silkworm cocoons after degumming to obtain silk fibroin freeze-dried powder. The polypeptide used in the present invention is a polypeptide obtained by self-screening. Compared with other polypeptides, it can specifically targetedly bind to human fibrinogen.

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Patent Owner(s)

Patent OwnerAddress
ZHEJIANG UNIVERSITY866 YUHANGTANG ROAD XIHU DISTRICT ZHEJIANG 310058

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Lei, Fang Zhejiang, CN 30 491
Shuai, Yajun Zhejiang, CN 1 0
Yang, Mingying Zhejiang, CN 3 0

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