Large scale production process for capped and un-capped antibody cysteines and their use in therapeutic protein conjugation

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United States of America Patent

PATENT NO 12121588
SERIAL NO

16480792

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Abstract

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Optimizing production of selectively capped, and uncapped, cysteines on antibodies by manipulation of cell growth conditions including the deliberate depletion of cysteine and/or cystine in the cell culture process by way of media components, batch duration, or cell density to achieve efficient production of proteins including antibody-drug-conjugates (ADCs).; conjugating a TNB-capped cysteine-containing protein by reacting it with a reducing agent capable of detaching the TNB-capping moieties from the protein without significantly reducing antibody inter-chain sulfur bonds, and conjugating reduced sulfur bonds on the protein to a payload through a reactive linking moiety.

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PFIZER INC235 EAST 42ND STREET ATTN LEGAL PATENT DEPARTMENT CHIEF IP COUNSEL NEW YORK NY 10017

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Dutta, Kaushik River Edge, US 8 46
Gomes, Jose Manuel Kingston, US 4 127
Kotch, Frank W Pearl River, US 3 12
Patel, Vimalkumar B Jersey City, US 1 0
Prashad, Amarnauth Shastrie New City, US 8 16
Procopio-Melino, Renee L Andover, US 1 0
Zhong, Xiaotian Wayland, US 12 48

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