Uses of salt-inducible kinase (SIK) inhibitors for treating osteoporosis

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United States of America Patent

PATENT NO 12121521
APP PUB NO 20220305016A1
SERIAL NO

17581818

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The present disclosure provides methods of treating and/or preventing osteoporosis using salt-inducible kinase (SIK) inhibitors. Also provided are methods of using SIK inhibitors for increasing the function of osteocytes, increasing the number of osteoblasts, increasing the activity of osteoblasts, inhibiting the resorption of a bone, decreasing the number of osteoclasts, inhibiting the activity of osteoclasts, increasing the mass of a bone, down-regulating the expression of the gene SOST, and/or inhibiting the activity of sclerostin. The SIK inhibitors may be combined with Src inhibitors or CSF1R inhibitors. Exemplary SIK inhibitors include the compounds of the formula:

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THE BROAD INSTITUTE INC415 MAIN STREET CAMBRIDGE MA 02142

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Choi, Hwan Geun Chestnut Hill, US 69 786
Gray, Nathanael S Stanford, US 247 2143
Kronenberg, Henry Boston, US 6 24
Liang, Yanke Belmont, US 54 471
Shamji, Alykhan Somerville, US 13 63
Sundberg, Thomas Boston, US 17 379
Wein, Marc Boston, US 4 10
Xavier, Ramnik Brookline, US 29 77

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