BCL-2 proteins degraders for cancer treatment

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United States of America Patent

PATENT NO 12118414
APP PUB NO 20210085675A1
SERIAL NO

16962816

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Abstract

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The present disclosure provides compositions and methods for selectively killing cancer cells, wherein the composition comprises a compound of Formula (I). The selective killing of cancer cells occurs with an improved potency and safety profile compared to similar compounds. In particular, the compositions and methods of the invention show reduced platelet toxicity and retained or improved toxicity in cancer cells.

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D-WAVE SYSTEMS INC3033 BETA AVENUE BURNABY V5G 4M9

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
He, Yonghan Little Rock, US 2 1
Khan, Sajid Little Rock, US 3 8
Zhang, Peiyi Little Rock, US 6 13
Zhang, Xuan Little Rock, US 201 1780
Zheng, Guangrong Little Rock, US 34 93
Zhou, Daohong Little Rock, US 20 94

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