Method for simultaneous analysis of neurotransmitters and their metabolites based on derivatization

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United States of America Patent

PATENT NO 12117457
SERIAL NO

17219023

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Abstract

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Disclosed is a method for simultaneous analysis of neurotransmitters and/or their metabolites. The method includes (a) separating analytes including a plurality of neurotransmitters and/or their metabolites from a sample selected from body tissues, body fluids, secretions, and excretions, (b) derivatizing the analytes with ethyl chloroformate to obtain derivatives of the plurality of neurotransmitters and/or their metabolites, (c) separating the derivatives of the plurality of neurotransmitters and/or their metabolites by liquid chromatography, and (d) subjecting the separated derivatives of the neurotransmitters or their metabolites to multiple reaction monitoring (MRM) using a mass spectrometer. According to the method, a plurality of neurotransmitters in a very small amount of sample can be simultaneously analyzed in an accurate and rapid manner based on derivatization to increase the stability and ionization efficiency of the substances.

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Patent Owner(s)

Patent OwnerAddress
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY5 HWARANG-RO 14-GIL SEONGBUK-GU SEOUL 02792 02792

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cho, Yoeseph Seoul, KR 2 0
Jeon, Seongeun Seoul, KR 1 0
Kwon, Oh-Seung Seoul, KR 13 263
Lee, Yejin Seoul, KR 6 0
Park, Hana Seoul, KR 2 2
Park, Jin Woo Seoul, KR 293 2321
Son, Junghyun Seoul, KR 4 5

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