Antimicrobial peptides

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United States of America Patent

PATENT NO 12116387
APP PUB NO 20230086360A1
SERIAL NO

17932077

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Abstract

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Provided herein are synthetic peptides with enhanced antimicrobial and antibiofilm characteristics, and are biocompatible with mammalian cellular systems. The disclosed synthetic antimicrobial moieties include a mastoparan peptide having SEQ ID NO:1 and a pentapeptide motif formed from phenylalanine, leucine, proline, and two isoleucine residues, wherein the pentapeptide motif is conjugated the N-terminus of the mastoparan peptide. Also provided are compositions comprising the synthetic peptides, as well as methods of treating a microbial infection or removing a biofilm using the peptides.

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Patent Owner(s)

Patent OwnerAddress
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA3600 CIVIC CENTER BOULEVARD 9TH FLOOR PHILADELPHIA PA 19104

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
de, la Fuente-Nunez Cesar Philadelphia, US 3 1
Der, Torossian Torres Marcelo Philadelphia, US 7 2
Franco, Octavio L Campo Grande, BR 2 1
Silva, Gislaine G O Campo Grande MS, BR 1 0

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