Binding proteins and chimeric antigen receptor T cells targeting GASP-1 granules and uses thereof

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United States of America Patent

PATENT NO 12110340
APP PUB NO 20190345256A1
SERIAL NO

16408510

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Abstract

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A method for detecting cells having granules expressing G protein coupled receptor-associated sorting protein 1 (GASP-1) or a fragment thereof is provided. The detection method may comprise: (a) contacting the cells with an effective amount of a binding protein, wherein the binding protein comprises an antigen binding fragment that specifically binds GASP-1; and (b) identifying cells having granules bound to the binding protein. The GASP-1 granules may be in the cytosol or on the surface of the cells. Also provided are methods for producing T-cells comprising a chimeric antigen receptor, anti-GASP-1 antibody or a bi-specific binding protein. Further provided are methods for treating GASP-1-mediated to disease or inactivating exosomes, microvesicles or oncosomes.

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Patent Owner(s)

  • PROPLEX TECHNOLOGIES, LLC

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chang, Frank N Dresher, US 18 170
Luo, Solomon Orwigsburg, US 3 1
Tuszynski, George P Pittsgrove, US 18 93
Yang, Jeff Bethesda, US 24 75

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