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United States of America

PATENT NO 12104189
SERIAL NO

17399423

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Abstract

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The disclosure discloses a mutant of nitrile hydratase derived from Caldalkalibacillus thermarum, and belongs to the technical field of enzyme engineering. The nitrile hydratase mutant Cal. t Nhase-A20V provided by the disclosure has a half-life of about 10 min at 70° C., which does not change much compared with the thermal stability of the wild enzyme. The specific enzyme activity of the mutant Cal. t Nhase-A20V is 128% of that of the wild enzyme. At the same time, the mutant also has better tolerance to a substrate and a product, and the final yield of nicotinamide produced by whole-cell catalysis reaches 598 g/L. Therefore, the nitrile hydratase mutant Cal. t Nhase-A20V provided by the disclosure has good enzymatic properties and is beneficial to future industrial production.

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Patent Owner(s)

Patent OwnerAddress
JIANGNAN UNIVERSITYDU YU NO 1800 LIHU AVENUE WUXI JIANGSU 214000 214000

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chen, Dezhi Wuxi, CN 6 5
Cheng, Zhongyi Wuxi, CN 7 0
Cui, Wenjing Wuxi, CN 11 1
Guo, Junling Wuxi, CN 11 1
Li, Ting Wuxi, CN 218 986
Liu, Zhongmei Wuxi, CN 10 1
Zhang, Sailan Wuxi, CN 1 0
Zhou, Li Wuxi, CN 253 2498
Zhou, Zhemin Wuxi, CN 10 1

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