Chiral resolution method mimicking magnetic beneficiation and the magnetic nano-inhibitors for selective enrichment

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United States of America Patent

PATENT NO 12104022
APP PUB NO 20210163695A1
SERIAL NO

17267156

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A core-shell nanocomposite is formed by co-assembly of an amphiphilic polymer and hydrophobically modified magnetic nanoparticles, with its core being a hydrophobically modified magnetic nanomaterial and its shell being the amphiphilic polymer, wherein hydrophilic segments in the amphiphilic polymer are located at an outermost layer of the shell. The above composite can be used as additives in the crystallization of conglomerates and obtain optically pure crystals of both enantiomers in a single process. The key thereof is that the composite is used to enrich molecules with the same configuration while inhibit the crystallization of the other enantiomer in a supersaturated solution of conglomerates, such that a non-magnetic crystal and a magnetic crystal (which are enantiomers of each other) are generated in a unit operation. Optically pure crystals of both enantiomers with over 90 ee % can be obtained by one-time crystallization, and the total yield can be as high as 40%.

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Patent Owner(s)

Patent OwnerAddress
PEKING UNIVERSITYNO 5 YIHEYUAN ROAD HAIDIAN DISTRICT BEIJING 100871

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Li, Bowen Beijing, CN 54 263
Wan, Xinhua Beijing, CN 1 0
Ye, Xichong Beijing, CN 1 0
Zhang, Jie Beijing, CN 1052 8750

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