FGF2 polypeptide with improved temperature stability and protease resistance and use thereof

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United States of America Patent

PATENT NO 12103953
APP PUB NO 20230076299A1
SERIAL NO

17779210

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Abstract

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Provided is a polypeptide having FGF2 activity and improved temperature stability and protease resistance. The polypeptide includes at least one substitution selected from a substitution of aspartic acid (D) with glutamic acid (E) at position 28, a substitution of cysteine (C) with isoleucine (I) or leucine (L) at position 78, or a substitution of cysteine (C) with isoleucine (I) or tryptophan (W) at position 96 in SEQ ID NO: 1.

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Patent Owner(s)

Patent OwnerAddress
KOREA INSTITUTE OF OCEAN SCIENCE TECHNOLOGYBUSAN 49111
CHA KIWEON#201 40-10 MANSU 1-GIL OSONG-EUP HEUNGDEOK-GU CHUNGCHEONGBUK-DO CHEONGJU-SI 28166

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
An, Young Jun Ansan-si, KR 6 9
Cha, Kiweon Cheongju-si, KR 7 28
Jeong, Ye Eun Busan, KR 5 25
Lee, Jung-Hyun Busan, KR 186 6824
Lee, Kyeong Won Busan, KR 6 17
Lee, Won Kyu Goyang-si, KR 40 406
Woo, Jurang Sejong, KR 1 0
Yim, Hyung-Soon Seoul, KR 6 0

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