Methods for producing peptide thioester and peptide

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United States of America Patent

PATENT NO 12103947
APP PUB NO 20230143844A1
SERIAL NO

17298125

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Abstract

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An object of the present invention is to provide a novel method having high efficiency and versatility for a peptide thioester and peptide. The present invention provides a method for producing a peptide thioester, comprising the steps of: (1) providing a peptide thioester having a CGC triplet at the C-terminal; (2) causing a transfer between an SH group of the C-terminal cysteine and a carbonyl group of the glycine in the CGC triplet to obtain an R-X-CG-thioester; and (3) causing, in the R-X-CG-thioester, a transfer between the SH group of the cysteine and a carbonyl group of X, and a transfer between an amino group of the cysteine and a thiol group of the glycine to obtain a peptide thioester, and a method for producing a peptide using the peptide thioester produced by this method.

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Patent Owner(s)

Patent OwnerAddress
GLYTECH INCKYOTO JAPAN KYOTO

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Amazaki, Yoko Osaka, JP 2 0
Kajihara, Yasuhiro Osaka, JP 39 125
Maki, Yuta Osaka, JP 2 0
Murase, Takefumi Kyoto, JP 6 0
Nishikawa, Rie Osaka, JP 7 26
Nomura, Kota Osaka, JP 16 18
Okamoto, Ryo Osaka, JP 9 1

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