Methods and systems for determining multi-column chromatography process configuration

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United States of America Patent

PATENT NO 12102941
APP PUB NO 20220040598A1
SERIAL NO

17383117

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The disclosure generally relates to methods and systems for determining multi-column chromatography process configuration for capturing antibodies. Conventional approaches for design of MCC configuration are limited to rule based, either driven by UV spectroscopic measurements or by performing number of experiments, which involves a lot of material costs and time utilization. The present disclosure solves the technical problem of identifying the operational conditions that optimized the MCC process and the MCC configuration. A multi-objective optimization function defined with one or more decision variables associated with the operating conditions is considered to determine the optimal MCC configuration, while satisfying purification goals. The one or more key performance measures of the MCC process comprises a productivity, a capacity utilization, a product yield, and a product purity. The significant amount of time and the material cost invested for designing the optimum MCC configuration is decreased by the present disclosure.

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Patent Owner(s)

Patent OwnerAddress
TATA CONSULTANCY SERVICES LIMITEDMUMBAI MAHARASHTRA 400 021

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Buddhiraju, Venkata Sudheendra Pune, IN 17 9
Masampally, Vishnu Swaroopji Pune, IN 11 7
Pareek, Aditya Pune, IN 12 12
Premraj, Karundev Pune, IN 4 0
Runkana, Venkataramana Pune, IN 69 75

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