Method for establishing biological model on joint toxicity of Caenorhabditis elegans and application thereof

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United States of America Patent

PATENT NO 12099051
APP PUB NO 20240118264A1
SERIAL NO

18371493

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A method for establishing a biological model on joint toxicity of Caenorhabditis elegans and an application thereof are provided. The method for establishing the biological model includes adding the L1-stage Caenorhabditis elegans to a mixed system of working solution of mycotoxins containing tenuazonic acid and penicillin, K-medium solution and E. coli OP50 to obtain L1-stage Caenorhabditis elegans. The biological model indicates that TeA and PAT have a synergistic effect on the growth, development and reproductive ability of Caenorhabditis elegans, and their toxicity mechanism is related to inducing nematodes and stimulating transcriptional factors of Daf-16 genes. The biological model and detection method are simple to operate and its test period is short.

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SOUTHWEST UNIVERSITY400715 NO 2 NATURAL ROAD BEIBEI DISTRICT CHONGQING CHONGQING CITY CHONGQING CITY 400715

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ma, Liang Chongqing, CN 261 1253
Zhang, Yuhao Chongqing, CN 32 105
Zhou, Hongyuan Chongqing, CN 1 0

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