Methods for decoupling yield and productivity of a non-catabolic compound produced by a host cell

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United States of America

PATENT NO 12098407
APP PUB NO 20220307059A1
SERIAL NO

17616843

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Abstract

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Provided herein are compositions and methods for uncoupling the yield and productivity of an isoprenoid compound produced in a host cell. In some embodiments, the yield and productivity are uncoupled by genetically modifying the host cell to reduce flux through the citric acid cycle (TCA). In other embodiments, the yield and productivity are uncoupled by reducing the levels of ATP in the host cell.

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Patent Owner(s)

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AMYRIS INC5885 HOLLIS STREET SUITE 100 EMERYVILLE CA 94608

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chua, Penelope R Emeryville, US 7 12
Jiang, Hanxiao Emeryville, US 11 17
Lerman, Joshua Adam Emeryville, US 2 6
Scherbart, Thomas Jon Emeryville, US 1 0
Thakker, Chandresh Emeryville, US 3 6
Tsong, Annie Ening Emeryville, US 6 76

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