Prevention of disulfide bond reduction during recombinant production of polypeptides

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United States of America Patent

PATENT NO 12098211
APP PUB NO 20230383004A1
SERIAL NO

18194471

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Abstract

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The invention concerns methods and means for preventing the reduction of disulfide bonds during the recombinant production of disulfide-containing polypeptides. In particular, the invention concerns the prevention of disulfide bond reduction during harvesting of disulfide-containing polypeptides, including antibodies, from recombinant host cell cultures.

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Patent Owner(s)

Patent OwnerAddress
GENENTECH INCCALIFORNIA USA CALIFORNIA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hewitt, Daniel P Sunnyvale, US 16 253
Kao, Yung-Hsiang San Mateo, US 27 637
Laird, Michael W San Ramon, US 41 488
Schmidt, Melody Trexler Danville, US 16 253
Wong, Rita L Redwood City, US 23 909

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